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Breakable foam of mupirocin for topical application on burn wounds: Statistical optimization and antimicrobial study by Vignesh Mohan; Sarika Wairkar is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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The objective of the study was to develop a topical foam formulation of mupirocin for the prevention and treatment of skin wounds, especially burn wounds. The pre-foam formulation was prepared by mixing oil and aqueous phase containing 2% mupirocin at 70 • C. This system was filled in the canister and crimped with aerosol propellant grade LPG to achieve pressurized foam. The foam formulation was statistically optimized by Box-Behnken design to check the effect of gelling agent (HPC), surfactant concentration (crodesta F110) and foaming adjuvants (oleyl and stearyl alcohol) on critical foam characteristics. These independent variables showed a significant effect on collapse time and foam density. The optimized formulation was evaluated for physicochemical properties, in vitro release and antibacterial activity. The optimum batch showed a collapse time of 85 s and had excellent spreadability. The diffusion study showed that more than 90% of the drug was released within 6 h. The formulation exhibited an antimicrobial effect against S. aureus which was 0.75-fold better than the marketed preparation of mupirocin. The foam-formulation has the unique nature of collapsing upon slight tap w

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Author

Vignesh Mohan; Sarika Wairkar

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)