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Bioavailability Evaluation of Perchlorate in Different Foods In Vivo : Comparison with In Vitro Assays and Implications for Human Health Risk Assessment by Xin Liu; Hu Zhang; Yimei Tian; Min Fang; Lin Xu; Qiao Wang; Jingguang Li; Haitao Shen; Yongning Wu; Zhiyong Gong is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Bioavailability Evaluation of Perchlorate in Different Foods In Vivo : Comparison with In Vitro Assays and Implications for Human Health Risk Assessment about?
Perchlorate in various foods continuously arouses public health concern. Bioavailability is a critical parameter to better estimate perchlorate exposure from diets. In this study, perchlorate bioavailability in five foods was determined in an in vivo mouse model and compared with in vitro bioaccessibility/bioavailability. The estimated in vivo perchlorate bioavailability for different foods ranged from 18.01 ± 4.53% to 45.60 ± 7.11%, with the order lettuce > pork > rice > milk powder > soybean. Moisture, fiber, and fat in foods were identified as critical factors affecting perchlorate bioavailability (correlation r = 0.71, 0.52, and -0.67, respectively). Linear regression analysis revealed that the in vitro perchlorate bioavailability determined using the Caco-2 cell model has the potential to estimate the in vivo perchlorate bioavailability in foods (R 2 = 0.67, slope = 1.33, and y intercept = 4.99). These findings provide insights into the effects of the food matrices on perchlorate bioavailability and could contribute to decrease the uncertainty regarding perchlorate dietary exposure risk assessment.
Who reads Bioavailability Evaluation of Perchlorate in Different Foods In Vivo : Comparison with In Vitro Assays and Implications for Human Health Risk Assessment?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Xin Liu; Hu Zhang; Yimei Tian; Min Fang; Lin Xu; Qiao Wang; Jingguang Li; Haitao Shen; Yongning Wu; Zhiyong Gong
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)