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Can I read Comparison of Doxycycline–streptomycin, Doxycycline–rifampin, and Ofloxacin–rifampin in the Treatment of Brucellosis: a Randomized Clinical Trial on EtoBox?
Comparison of Doxycycline–streptomycin, Doxycycline–rifampin, and Ofloxacin–rifampin in the Treatment of Brucellosis: a Randomized Clinical Trial by Seyyed Hamid Hashemi; Latif Gachkar; Fariba Keramat; Mojgan Mamani; Mehrdad Hajilooi; Alireza Janbakhsh; Mohammad Mehdi Majzoobi; Hossein Mahjub is a Medicine article available to read on EtoBox.
What is Comparison of Doxycycline–streptomycin, Doxycycline–rifampin, and Ofloxacin–rifampin in the Treatment of Brucellosis: a Randomized Clinical Trial about?
## Background: Traditional regimens for the treatment of brucellosis are associated with significant relapse rates. the aim of this study was to compare the efficacy of ofloxacin plus rifampin (ofx-rif) versus doxycycline plus streptomycin (dox-str) and doxycycline plus rifampin (dox-rif) regimens in the treatment of brucellosis. ## Methods: Two hundred and nineteen patients with brucellosis were enrolled in a randomized clinical trial; 28 cases were withdrawn because they did not attend the follow-up. out of 191 patients with brucellosis, 64 received ofx-rif, 62 received dox-rif, and 65 patients received dox-str regimens. all patients were assessed during the period of therapy in the second, fourth, and sixth weeks by clinical course and were also followed up clinically and serologically for 6 months after the cessation of therapy. ## Results: The highest clinical response (95.4%) was observed in the dox-str group (p=0.009). the results of multivariate analysis indicate that treatment with dox-str had the least therapeutic failures among the three groups (p=0.033). adverse reactions were seen in 16.8% of patients, but there was no significant difference among the three groups (p=0
Who reads Comparison of Doxycycline–streptomycin, Doxycycline–rifampin, and Ofloxacin–rifampin in the Treatment of Brucellosis: a Randomized Clinical Trial?
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- Author
- Seyyed Hamid Hashemi; Latif Gachkar; Fariba Keramat; Mojgan Mamani; Mehrdad Hajilooi; Alireza Janbakhsh; Mohammad Mehdi Majzoobi; Hossein Mahjub
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1201-9712)
- Published
- 2012
- Language
- EN
- Field
- Medicine (Health Sciences)