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Hepatic Complications of Bone Marrow Transplantation by Kelly K. Curtis; James L. Slack; Hugo E. Vargas is a book available to read on EtoBox.

What is Hepatic Complications of Bone Marrow Transplantation about?

Hepatic complications of hematopoietic stem cell transplantation (HSCT) are common. Sinusoidal obstruction syndrome (SOS), acute/chronic hepatic graft -versus -host disease (HGVHD), infection, and drug -induced hepatotoxicity (DIH) are the most common reasons for liver abnormalities following HSCT.SOS, characterized by rapid weight gain due to fl uid retention, hyperbilirubinemia, and hepatomegaly with right upper quadrant pain, can be diffi cult to diagnose. Liver biopsy is the gold standard. Treatment options include tissue -type plasminogen activator with heparin, defi brotide, and antithrombin III. A majority of patients recover.Acute HGVHD generally occurs with skin and gastrointestinal tract GVHD. Chronic HGVHD presents with other manifestations of chronic GVHD, closely resembling an autoimmune disorder much like scleroderma. Immunosuppression is the mainstay of therapy, with a majority of patients requiring long -term treatment.Viral, fungal, and bacterial infections, as well as DIH, are also common after HSCT. Treatment with appropriate antibiotics, or withholding liver -toxic medications, results in liver function improvement for most patients.

Author

Kelly K. Curtis; James L. Slack; Hugo E. Vargas

Publisher

Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)

Published

2010

Language

EN

ISBN

9781282729223

Subjects

Medical, Medicine