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Can I read Effects of Concurrent Cisplatinum Administration During Radiotherapy vs. Radiotherapy Alone on the Immune Function of Patients with Cancer of the Uterine Cervix on EtoBox?
Effects of Concurrent Cisplatinum Administration During Radiotherapy vs. Radiotherapy Alone on the Immune Function of Patients with Cancer of the Uterine Cervix by Alessandro D Santin; Paul L Hermonat; Antonella Ravaggi; Stefania Bellone; Juan Roman; Sergio Pecorelli; Martin Cannon; Groesbeck P Parham is a Medicine article available to read on EtoBox.
What is Effects of Concurrent Cisplatinum Administration During Radiotherapy vs. Radiotherapy Alone on the Immune Function of Patients with Cancer of the Uterine Cervix about?
## Purpose: To compare the effects of concurrent administration of cisplatinum (40 mg/m(2)/weekly) with radiation therapy (c-rt) to those induced by radiation therapy alone (rt) on the immune function of patients with locally advanced cervical cancer. ## Methods and materials: In 8 prospectively randomized patients (i.e., 4 receiving rt vs. 4 receiving c-rt), lymphocyte populations including cd3+, cd4+ and cd8+ t-cell subsets, b cells (cd19+) and natural killer cells (cd56+, cd16+, cd3-) were studied before, during, and after therapy. expression of the activation marker cd25 on cd3+ t cells, intracellular levels of perforin in cd8+ and cd56+ cells, and interferon-gamma (ifn-gamma) and il-2 in cd4+ and cd8+ t cells was also measured. finally, lymphoblast transformation and natural killer (nk) cytotoxic activity were assessed. ## Results: Both rt and c-rt significantly decreased the mean absolute number of all lymphocyte subsets compared to pretreatment levels (p > 0.001). however, no differences were detected in the characteristics or the magnitude of the lymphopenia induced by the two treatments. both rt and c-rt increased similarly the percentages of cd25-positive lymphocytes (p >
Who reads Effects of Concurrent Cisplatinum Administration During Radiotherapy vs. Radiotherapy Alone on the Immune Function of Patients with Cancer of the Uterine Cervix?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alessandro D Santin; Paul L Hermonat; Antonella Ravaggi; Stefania Bellone; Juan Roman; Sergio Pecorelli; Martin Cannon; Groesbeck P Parham
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)