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Circ‐EIF3I facilitates proliferation, migration, and invasion of lung cancer via regulating the activity of Wnt/β‐catenin pathway through the miR‐1253/NOVA2 axis by Tao Chen; Guangqiang Feng; Zhisong Xing; Xingcai Gao is a Medicine article available to read on EtoBox.

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## Abstract Many studies have shown that circular RNA (circRNA) is an important regulator mediating the malignant progression of cancer. However, the role and mechanism of circ‐EIF3I in lung cancer (LC) development are still unclear. A total 36 paired LC tumor tissues and adjacent normal tissues were enrolled. The expression of circ‐EIF3I, microRNA (miR)‐1253, and neuro‐oncological ventral antigen 2 (NOVA2) was measured by quantitative real‐time PCR. The proliferation, apoptosis, migration, and invasion of LC cells were determined by MTT assay, colony formation assay, flow cytometry, and transwell assay. Dual‐luciferase reporter assay was performed to verify the interaction between miR‐1253 and circ‐EIF3I or NOVA2. The protein levels of NOVA2 and Wnt/β‐catenin pathway‐related markers were detected by western blot analysis. Xenograft tumor was constructed to explore the function of circ‐EIF3I on LC tumor growth. Circ‐EIF3I was upregulated in LC tumor tissues and cells. Silenced circ‐EIF3I could suppress the proliferation, migration, invasion, and enhance the apoptosis of LC cells in vitro, as well as reduce LC tumor growth in vivo. Circ‐EIF3I could sponge miR‐1253, and miR‐1253 inhi

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Author

Tao Chen; Guangqiang Feng; Zhisong Xing; Xingcai Gao

Published

2022

Language

EN

Field

Medicine (Health Sciences)