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Association of Ezrin Isoforms with the Neuronal Cytoskeleton by E. Brigbauer; J. H. Dinsmore; B. Winckler; A. D. Lander; F. Solomon is a Neuroscience article available to read on EtoBox.

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## Abstract We are studying the changes in the organization of the cytoskeleton which accompany expression of differentiated neuronal morphology. Of particular interest is the elaboration of growth cones, the motile domains of the neuronal plasma membrane, and the cytoskeletal structures that underlie them. A candidate for a component of the growth cone cytoskeleton of cultured hippocampal neurons is the antigen recognized by the monoclonal antibody, 13H9 (Birgbauer and Solomon, __J Cell Biol__ 109:1609–1620, 1989; Goslin et al., __J Cell Biol__ 109:1621–1631, 1989). That antibody binds strongly to growth cones, but barely stains neurites. The characterization of the antigen, both biochemical and microscopic, suggests that it may interact with microfilaments and microtubules. We have established that 13H9 recognizes a subset of the isoforms of ezrin (unpublished results). Here, we describe the properties and localization of ezrin isoforms in differentiating neuronal cells, using two in vitro systems and developing spinal cord. In embryonal carcinoma cells, both the abundance of ezrin and the proportion of ezrin associated with the cytoskeletal fraction increase upon induction of ne

Who reads Association of Ezrin Isoforms with the Neuronal Cytoskeleton?

Author

E. Brigbauer; J. H. Dinsmore; B. Winckler; A. D. Lander; F. Solomon

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1991

Language

EN

Field

Neuroscience (Life Sciences)