Opening book details…
Can I read Preparation of alginate magnetic nanoparticles based on Fe3O4 as anticancer drug delivery vehicle: imatinib loading and in vitro release study on EtoBox?
Preparation of alginate magnetic nanoparticles based on Fe3O4 as anticancer drug delivery vehicle: imatinib loading and in vitro release study by Shirin Kalani; Elham Moniri; Seyed Abolhassan Alavi; Raheleh Safaeijavan is a Materials Science article available to read on EtoBox.
What is Preparation of alginate magnetic nanoparticles based on Fe3O4 as anticancer drug delivery vehicle: imatinib loading and in vitro release study about?
In this study, a novel nanocarrier based on magnetic nanoparticles was synthesized via a facile method and modified by alginate. The synthesized nanocarrier was characterized using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis, Brunauer-Emmett-Teller, vibrating sample magnetometer, and x-ray diffraction analysis. Different factors were optimized to evaluate the adsorption of imatinib on the nanoadsorbent. Imatinib was chosen as an anti-cancer drug, and the release rate of imatinib was investigated in simulated human blood (pH = 7.4) and simulated cancer (pH = 5.6) fluids. The drug adsorption isotherms, kinetics, and thermodynamics were studied. Based on the equilibrium adsorption results, the Langmuir isotherm and the pseudo-second-order kinetic models indicated a better fit than other models. Values of the enthalpy and entropy for drug sorption on the nanoadsorbent were positive. The negative value of Gibbs free energy reveals the spontaneous and feasible adsorption of imatinib on the nanoadsorbent.
Who reads Preparation of alginate magnetic nanoparticles based on Fe3O4 as anticancer drug delivery vehicle: imatinib loading and in vitro release study?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Shirin Kalani; Elham Moniri; Seyed Abolhassan Alavi; Raheleh Safaeijavan
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)
More by Shirin Kalani; Elham Moniri; Seyed Abolhassan Alavi; Raheleh Safaeijavan
Browse all works by Shirin Kalani; Elham Moniri; Seyed Abolhassan Alavi; Raheleh Safaeijavan