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Diabetes and Impaired Glucose Tolerance in Patients with Polycystic Ovary Syndrome--a Long Term Follow-up by M. Hudecova; J. Holte; M. Olovsson; A. Larsson; C. Berne; I. S. Poromaa is a Medicine article available to read on EtoBox.

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## Background: The overall risk of developing diabetes mellitus and glucose intolerance seems to be higher in women with polycystic ovary syndrome (pcos) than in healthy women. the aim of this long-term follow-up study was to examine glucose tolerance and insulin sensitivity in middle-aged women previously diagnosed with pcos in comparison with age-matched healthy controls. ## Methods: Women diagnosed with pcos between 1987 and 1995 were invited to participate in the study. a total of 84 pcos patients and 87 control subjects participated. anthropometric (bmi, waist/hip ratio) and metabolic parameters (oral glucose tolerance test) were measured. insulin sensitivity was expressed by the matsuda index and beta cell function by the insulinogenic index. pcos women were subgrouped according to phenotype at the index assessment (with or without hyperandrogenism) and persistence of pcos symptoms at the follow-up (persisting or resolved pcos). ## Results: Eighteen (21.4%) pcos patients and four (4.5%) controls had developed type 1 or type 2 diabetes or impaired glucose tolerance (igt) at the follow-up investigation (p < 0.05). matsuda insulin sensitivity index was lower and the insulinogeni

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Author

M. Hudecova; J. Holte; M. Olovsson; A. Larsson; C. Berne; I. S. Poromaa

Publisher

Oxford University Press; Oxford University Press (OUP) (ISSN 0268-1161)

Published

2011

Language

EN

Field

Medicine (Health Sciences)