Can I read Regulative Beeinflussung der Nourseothricinbiosynthese durch O-Aminobenzoesäure in Kulturen des Streptomyces noursei JA 3890b on EtoBox?

Regulative Beeinflussung der Nourseothricinbiosynthese durch O-Aminobenzoesäure in Kulturen des Streptomyces noursei JA 3890b by Dr. U. Gräfe; H. Bocker; G. Reinhardt; H. Thrum is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Regulative Beeinflussung der Nourseothricinbiosynthese durch O-Aminobenzoesäure in Kulturen des Streptomyces noursei JA 3890b about?

## Abstract The biosynthesis of nourseothricin, a streptothricin type antibiotic, is strongly stimulated by __o__‐aminobenzoic acid in cultures of __S. noursei__ JA 3890 b. __o__‐Aminobenzoic acid (OAB) was shown to interfere with the amino acid metabolism and to influence last not least the efficacy of the precursor supplying system in the antibiotic biosynthesis. Thus, mycelium cultivated in presence of OAB (7.5 mM) exhibits strongly increased activities of NADP‐specific glutamate dehydrogenase. Simultaneously, this effector prevents the induction of alanine dehydrogenase in productive cultures suggesting that an enhanced formation of alanine interferes with antibiotic biosynthesis. Insignificant variations of further enzymic activities, __e.g.__ of transaminases, of phosphoenolpyruvate carboxylase and of enzymes of the tricarboxylic acid cycle were observed. Furthermore, the possible role of __o__‐aminobenzoic acid as an effector of metabolite transport systems or of energy metabolism is discussed.

Who reads Regulative Beeinflussung der Nourseothricinbiosynthese durch O-Aminobenzoesäure in Kulturen des Streptomyces noursei JA 3890b?

Author

Dr. U. Gräfe; H. Bocker; G. Reinhardt; H. Thrum

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Akademie Verlag; Wiley (ISSN 0233-111X)

Published

1974

Language

DE

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)