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The Midline Thalamus: Alterations and a Potential Role in Limbic Epilepsy by Edward H. Bertram; Patrick S. Mangan; DeXing Zhang; Carol A. Scott; John M. Williamson is a Medicine article available to read on EtoBox.

What is The Midline Thalamus: Alterations and a Potential Role in Limbic Epilepsy about?

**Summary:** **Purpose:** In limbic or mesial temporal lobe epilepsy, much attention has been given to specific regions or cell populations (e.g., the hippocampus or dentate granule cells). Epileptic seizures may involve broader changes in neural circuits, and evidence suggests that subcortical regions may play a role. In this study we examined the midline thalamic regions for involvement in limbic seizures, changes in anatomy and physiology, and the potential role for this region in limbic seizures and epilepsy **Methods:** Using two rat models for limbic epilepsy (hippocampal kindled and chronic spontaneous limbic epilepsy) we examined the midline thalamus for evidence of involvement in seizure activity, alterations in structure, changes in the basic in vitro physiology of the thalamic neurons. We also explored how this region may influence limbic seizures. **Results:** The midline thalamus was consistently involved with seizure activity from the onset, and there was significant neuronal loss in the medial dorsal and reuniens/rhomboid nuclei. In addition, thalamic neurons had changes in synaptically mediated and voltage‐gated responses. Infusion of lidocaine into the midline tha

Who reads The Midline Thalamus: Alterations and a Potential Role in Limbic Epilepsy?

Author

Edward H. Bertram; Patrick S. Mangan; DeXing Zhang; Carol A. Scott; John M. Williamson

Publisher

Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0013-9580)

Published

2001

Language

EN

Field

Medicine (Health Sciences)