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Pyrrolo-quinoline Derivatives as Potential Antineoplastic Drugs by M.G Ferlin; B Gatto; G Chiarelotto; M Palumbo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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AbstractÐSome novel pyrrolo-quinoline derivatives have been synthesized as potential antineoplastic agents. They contain an angular aromatic tricyclic or tetracyclic system, to which the methanesulfon-anisidide side chain typical of amsacrine as such, or lacking the m-methoxy substituent, is connected. A methyl group can be present at position 7 of the pyrrolo-quinoline ring. The novel compounds exhibit interesting cell growth inhibitory properties when tested against the NCI panel of cell lines, in particular those obtained from solid tumors like CNS-, melanoma-and prostate-derived cells. The mechanism of cytotoxic action does not seem to be related to topoisomerase II poisoning ability. Most active proved to be compound 4a, which lacks both methyl and methoxy substituents, followed by 5a, having the methoxy group only. Biological activity is less pronounced in the tetracyclic family of derivatives 6 and 7.

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Author

M.G Ferlin; B Gatto; G Chiarelotto; M Palumbo

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)