Can I read Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides on EtoBox?
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides by Laval Chan; Oswy Pereira; T.Jagadeeswar Reddy; Sanjoy K. Das; Carl Poisson; Marc Courchesne; Mélanie Proulx; Arshad Siddiqui; Constantin G. Yannopoulos; Nghe Nguyen-Ba; Caroline Roy; Daniel Nasturica; Christophe Moinet; Richard Bethell; Martine Hamel; Lucille L'Heureux; Maud David; Olivier Nicolas; Philippe Courtemanche-Asselin; Stéphanie Brunette; Darius Bilimoria; Jean Bédard is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides about?
Further SAR studies on the thiophene-2-carboxylic acids are reported. These studies led to the identification of a series of tertiary amides that show inhibition of both HCV NS5B polymerase in vitro and HCV subgenomic RNA replication in Huh-7 cells. Structural insights about the bioactive conformation of this class of molecules were deduced from a combination of modeling and transferred NOE (trNOE) studies.
Who reads Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Laval Chan; Oswy Pereira; T.Jagadeeswar Reddy; Sanjoy K. Das; Carl Poisson; Marc Courchesne; Mélanie Proulx; Arshad Siddiqui; Constantin G. Yannopoulos; Nghe Nguyen-Ba; Caroline Roy; Daniel Nasturica; Christophe Moinet; Richard Bethell; Martine Hamel; Lucille L'Heureux; Maud David; Olivier Nicolas; Philippe Courtemanche-Asselin; Stéphanie Brunette; Darius Bilimoria; Jean Bédard
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)