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Alcohol dependence and glutamate decarboxylase gene polymorphisms in an Italian male population by Claudio Terranova; Marianna Tucci; Giovanni Forza; Luisa Barzon; Giorgio Palù; Santo Davide Ferrara is a Medicine article available to read on EtoBox.

What is Alcohol dependence and glutamate decarboxylase gene polymorphisms in an Italian male population about?

Knowledge of alcohol use disorder and of substance-related problems has recently found some initial support in genetic studies. With a view to further understanding of this particular aspect, in the light of the ''self-medication hypothesis,'' we focused our attention on the gamma aminobutyric acid system and, in particular, on single nucleotide polymorphisms (SNPs) in the glutamate decarboxylase 67 or glutamic acid decarboxylase 67 (GAD67) gene region in association with alcohol dependence. The research was structured as a caseecontrol study. The patient cohort included 283 Caucasian males from the Veneto region, North-east Italy; 107 were alcohol dependent according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV TR) criteria, and 176 were controls recruited from blood donors. We analyzed 26 SNPs located in the coding and untranslated regions of the GAD67 gene with the GenomeLab SNPStream Genotyping System (Beckman Coulter, Fullerton, CA). Fisher's Chi-square test for allele and genotype distributions and HardyeWeinberg equilibrium analysis for cases and controls were performed. Ten SNPs at the GAD67 gene were valid for further statistics. Preliminary results

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Author

Claudio Terranova; Marianna Tucci; Giovanni Forza; Luisa Barzon; Giorgio Palù; Santo Davide Ferrara

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2010

Language

EN

Field

Medicine (Health Sciences)