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Interobserver Variation of Clinical Target Volume Delineation in Gastric Cancer by Edwin P.M. Jansen; Jasper Nijkamp; Michael Gubanski; Pehr A.R.M. Lind; Marcel Verheij is a Medicine article available to read on EtoBox.
What is Interobserver Variation of Clinical Target Volume Delineation in Gastric Cancer about?
Purpose: To evaluate interobserver variability in clinical target volume (CTV) delineation in gastric cancer performed with the help of a delineation guide. Patients and Methods: Ten radiotherapy centers that participate in the CRITICS Phase III trial were provided with a delineation atlas, preoperative CT scans, a postoperative planning CT scan, and clinical information for a gastric cancer case and were asked to construct a CTV and create a dosimetric plan according to departmental policy. Results: The volumes of the CTVs and planning target volumes (PTVs) differed greatly, with a mean (SD) CTV volume of 392 (176) cm 3 (range, 240-821cm 3 ) and PTV volume of 915 (312) cm 3 (range, 634-1677cm 3 ). The overlapping volume was 376cm 3 for the CTV and 890cm 3 for the PTV. The greatest differences in the CTV were seen at the cranial and caudal parts. After planning, dose coverage of the overlapping PTV volume showed less variability than the CTV. Conclusion: In this series of 10 plans, variability of the CTV in postoperative chemoradiotherapy for gastric cancer is large. Strict and clear delineation guidelines should be provided, especially in Phase III multicenter studies. Adaptations
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- Author
- Edwin P.M. Jansen; Jasper Nijkamp; Michael Gubanski; Pehr A.R.M. Lind; Marcel Verheij
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)