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Growth response to rhIGF‐I 80 μg/kg twice daily in children with growth hormone insensitivity syndrome: relationship to severity of clinical phenotype by Cristina Azcona; Michael A. Preece; Stephen J. Rose; Neil Fraser; Raphaël Rappaport; Michael B. Ranke; Martin O. Savage is a Medicine article available to read on EtoBox.

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## BACKGROUND rhIGF‐I has been used effectively to promote growth in growth hormone insensitivity syndrome (GHIS) in doses ranging from 40 μg/kg twice daily to 150–200 μg/kg once daily. It appears that the dose of 80 μg/kg twice daily s.c. may induce an equivalent response to higher doses with less side‐effects. ## OBJECTIVE To study the efficacy and safety of rhIGF‐I, 80 μg/kg twice daily s.c., in children with GHIS and to analyse the relationship of growth response to severity of phenotype. ## PATIENTS AND DESIGN: Eleven prepubertal children (3 females, 8 males) with GHIS; basal GH > 2.5 μg/l, IGF‐I < 50 μg/l, IGFBP‐3 < − 2SD; were treated with IGF‐I 80 μg/kg twice daily in a multi‐centre study. The baseline characteristics of these patients were as follows (mean ± SD): age, 7.5 ± 2.5 years (range, 2.5–11.7 years), bone age (Tanner–Whitehouse − 2 RUS), 5.2 ± 2.4 years (range, 2.3–9.1 years), mean height SDS, − 5.6 ± 1.6 (range, − 3.1 to − 8.1), height velocity (HV), 3.1 ± 1.1 cm/year (range, 1.9–4.9 cm/year). Height, HV, weight, skinfold thickness, puberty stage and bone age were measured at baseline and 6 monthly for 2 years. ## RESULTS During the first 12 months of IGF‐I therap

Who reads Growth response to rhIGF‐I 80 μg/kg twice daily in children with growth hormone insensitivity syndrome: relationship to severity of clinical phenotype?

Author

Cristina Azcona; Michael A. Preece; Stephen J. Rose; Neil Fraser; Raphaël Rappaport; Michael B. Ranke; Martin O. Savage

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

1999

Language

EN

Field

Medicine (Health Sciences)