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Can I read Transforming Viruses Directly Reduce the Cellular Growth Requirement for a Platelet Derived Growth Factor on EtoBox?
Transforming Viruses Directly Reduce the Cellular Growth Requirement for a Platelet Derived Growth Factor by Charles D. Scher; W. J. Pledger; Paul Martin; Harry Antoniades; Charles D. Stiles is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Transforming Viruses Directly Reduce the Cellular Growth Requirement for a Platelet Derived Growth Factor about?
## Abstract Early passage mouse embryo fibroblasts, mouse 3T3 cell lines, and early passage diploid human fibroblasts grew to higher cell densities in tissue culture medium supplemented with serum than in medium supplemented with defibrinogenated platelet‐poor plasma (PPP). Unlike the mouse cells, the human fibroblasts displayed this differential growth response only in the presence of hypophysiologic concentrations of calcium. The addition of heat‐treated extracts of human platelets to PPP‐supplemented medium stimulated the replication of both the normal mouse cells and early passage human embryo fibroblasts. Human or mouse fibroblasts transformed by either retroviruses or by SV40, including SV40 infected “serum revertants” and “flat transformants,” grew to equal cell densities in medium supplemented with either serum or PPP. Infection of Balb/c‐3T3 cells with SV40 rapidly induced them to grow in PPP‐supplemented medium demonstrating that the ability of SV40‐transformed cell lines to proliferate in PPP‐supplemented medium does not arise from the cell culture selection procedures usually employed to obtain stable virus‐transformed cell lines. 3T3 cells infected but not transformed
Who reads Transforming Viruses Directly Reduce the Cellular Growth Requirement for a Platelet Derived Growth Factor?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Charles D. Scher; W. J. Pledger; Paul Martin; Harry Antoniades; Charles D. Stiles
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1978
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)