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Cardiac Lipid Content Is Unresponsive to a Physical Activity Training Intervention in Type 2 Diabetic Patients, Despite Improved Ejection Fraction by Vera B Schrauwen-Hinderling; Ruth CR Meex; Matthijs KC Hesselink; Tineke van de Weijer; Tim Leiner; Michael Schär; Hildo J Lamb; Joachim E Wildberger; Jan FC Glatz; Patrick Schrauwen; M Eline Kooi is a Medicine article available to read on EtoBox.

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## Background Increased cardiac lipid content has been associated with diabetic cardiomyopathy. We recently showed that cardiac lipid content is reduced after 12 weeks of physical activity training in healthy overweight subjects. The beneficial effect of exercise training on cardiovascular risk is well established and the decrease in cardiac lipid content with exercise training in healthy overweight subjects was accompanied by improved ejection fraction. It is yet unclear whether diabetic patients respond similarly to physical activity training and whether a lowered lipid content in the heart is necessary for improvements in cardiac function. Here, we investigated whether exercise training is able to lower cardiac lipid content and improve cardiac function in type 2 diabetic patients. ## Methods Eleven overweight-to-obese male patients with type 2 diabetes mellitus (age: 58.4 ± 0.9 years, BMI: 29.9 ± 0.01 kg/m^2^) followed a 12-week training program (combination endurance/strength training, three sessions/week). Before and after training, maximal whole body oxygen uptake (VO2max) and insulin sensitivity (by hyperinsulinemic, euglycemic clamp) was determined. Systolic function was d

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Author

Vera B Schrauwen-Hinderling; Ruth CR Meex; Matthijs KC Hesselink; Tineke van de Weijer; Tim Leiner; Michael Schär; Hildo J Lamb; Joachim E Wildberger; Jan FC Glatz; Patrick Schrauwen; M Eline Kooi

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1475-2840)

Published

2011

Language

EN

Field

Medicine (Health Sciences)