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Can I read Landscape of neoadjuvant therapy in HER2-positive breast cancer: a systematic review and network meta-analysis on EtoBox?
Landscape of neoadjuvant therapy in HER2-positive breast cancer: a systematic review and network meta-analysis by Guillermo Villacampa; Alexios Matikas; Mafalda Oliveira; Aleix Prat; Tomás Pascual; Andri Papakonstantinou is a Medicine article available to read on EtoBox.
What is Landscape of neoadjuvant therapy in HER2-positive breast cancer: a systematic review and network meta-analysis about?
Background The recommended preoperative approach for HER2-positive breast cancer is unclear. We aimed to investigate the following: i) what is the optimal neoadjuvant regimen and ii) whether anthracyclines could be excluded. Methods A systematic literature search in Medline, Embase and Web of Science databases was performed. Studies had to satisfy the following criteria: i) randomised controlled trials (RCTs), ii) enroled patients treated preoperatively for HER2-positive BC (breast cancer), iii) at least one treatment group received an anti-HER2 agent, iv) available information of any efficacy end-point and v) published in English. A network meta-analysis with a frequentist framework using random-effects model was used to pool direct and indirect evidence. Pathologic complete response (pCR), event-free survival (EFS) and overall survival (OS) were the efficacy end-points of interest, and selected safety end-points were also analysed. Results A total of 11,049 patients with HER2-positive BC (46 RCTs) were included in the network meta-analysis, and 32 different regimens were evaluated. Dual anti-HER2-therapy, with pertuzumab or tyrosine kinase inhibitors, combined with chemotherapy w
Who reads Landscape of neoadjuvant therapy in HER2-positive breast cancer: a systematic review and network meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Guillermo Villacampa; Alexios Matikas; Mafalda Oliveira; Aleix Prat; Tomás Pascual; Andri Papakonstantinou
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)