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Can I read 674. Variations in Agreement and Epidemiological Cutoff Value (ECV) between Fosfomycin (FOF) Agar Dilution and Broth Microdilution Using Standard- and High-Inoculum Protocols for Klebsiella pneumoniae (KP) on EtoBox?
674. Variations in Agreement and Epidemiological Cutoff Value (ECV) between Fosfomycin (FOF) Agar Dilution and Broth Microdilution Using Standard- and High-Inoculum Protocols for Klebsiella pneumoniae (KP) by Krueger, Amanda R ;Anderson, Jadyn C ;Smith, Elizabeth C ;Bixby, Morgan L ;Brigman, Hunter V ;Hirsch, Elizabeth B is a Medicine article available to read on EtoBox.
What is 674. Variations in Agreement and Epidemiological Cutoff Value (ECV) between Fosfomycin (FOF) Agar Dilution and Broth Microdilution Using Standard- and High-Inoculum Protocols for Klebsiella pneumoniae (KP) about?
## Abstract ## Background FOF has been used in the treatment of multidrug-resistant (MDR) KP infections despite established susceptibility breakpoints. At present, agar dilution (AD) is considered the reference method for FOF while broth microdilution (BMD) is specifically recommended against despite its convenience over AD. We therefore sought to assess FOF activity against KP, along with essential and categorical agreement between AD and BMD methods to determine if BMD could be used as a reliable testing method. ## Methods Minimal inhibitory concentration (MIC) values were determined for a convenience collection of 69 KP isolates (59.4% MDR) from three US institutions. MIC testing was conducted in duplicate on separate days using AD and BMD methods; essential and categorical agreement were calculated using AD as the reference method. Fourteen isolates were also analyzed using high-inoculum AD (10^5.3-5.9^ CFU/mL) similar to the BMD method. MIC values were categorized using Clinical and Laboratory Standards Institute (CLSI) interpretive criteria for __Escherichia coli__ (≤ 64 mg/L, susceptible). ECVs were determined according to CLSI methodology. ## Results MIC values varied betwe
Who reads 674. Variations in Agreement and Epidemiological Cutoff Value (ECV) between Fosfomycin (FOF) Agar Dilution and Broth Microdilution Using Standard- and High-Inoculum Protocols for Klebsiella pneumoniae (KP)?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Krueger, Amanda R ;Anderson, Jadyn C ;Smith, Elizabeth C ;Bixby, Morgan L ;Brigman, Hunter V ;Hirsch, Elizabeth B
- Publisher
- Oxford University Press (OUP)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)