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Adenosine A~1~ and A~2A~ receptor regulation of protein phosphatase 2A in the murine heart by Eugene I. Tikh; Richard A. Fenton; Jiang-Fan Chen; Michael A. Schwarzschild; James G. Dobson Jr. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Adenosine A~1~ and A~2A~ receptor regulation of protein phosphatase 2A in the murine heart about?
## Abstract Adenosine plays a role in regulating the contractile function of the heart. This includes a positive ionotropic action via the adenosine A~2A~ receptor (A~2A~R) and an inhibition of β~1~‐adrenergic receptor‐induced ionotropy (antiadrenergic action) via the adenosine A~1~ receptor (A~1~R). Phosphatase activity has also been shown to influence contractile function by affecting the level of protein phosphorylation. Protein phosphatase 2A (PP2A) plays a significant role in mediating the A~1~R antiadrenergic effect. The purpose of this study was to investigate the effects of A~2A~R and A~1~R on the activities of PP2A in hearts obtained from wild‐type (WT) and A~2A~R knockout (A~2A~R‐KO) mice. PP2A activities were examined in myocardial particulate and cytoplasmic extract fractions. Treatment of wild‐type hearts with the A~1~R agonist CCPA increased the total PP2A activity and increased the particulate:cytoplasmic PP2A activity ratio. Treatment with the A~2A~R agonist CGS‐21680 (CGS) decreased the total PP2A activity and decreased the particulate:cytoplasmic PP2A activity ratio. This indicated a movement of PP2A activity between cell fractions. The effect of CCPA was inhibite
Who reads Adenosine A~1~ and A~2A~ receptor regulation of protein phosphatase 2A in the murine heart?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Eugene I. Tikh; Richard A. Fenton; Jiang-Fan Chen; Michael A. Schwarzschild; James G. Dobson Jr.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)