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Sedative-hypnotic Effects of Midazolam in Goats After Intravenous and Intramuscular Administration by G F Stegmann; L Bester is a Veterinary article available to read on EtoBox.

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## Objective: To examine the effect of dose and route of administration on the sedative-hypnotic effects of midazolam. ## Design: Prospective randomized controlled study animals: six indigenous, african bred goats. ## Methods: Pilot studies indicated that the optimum dose of midazolam for producing sedation was 0.6 mg kg for intramuscular (im) injection, while the optimum intravenous (iv) doses causing hypnosis without, and with loss of palpebral reflexes were 0.6 mg kg and 1.2 mg kg, respectively. these doses and routes of administration were compared with a saline placebo in a randomized block design in the main experiment, and the sedative-hypnotic effects evaluated according to pre-determined scales. ## Results: Intramuscular midazolam produced sedation with or without sternal recumbency in all animals with the peak effect occurring 20 minutes after administration. the scores for im sedation with midazolam were significantly different (p < 0.05) from placebo. intravenous midazolam at 0.6 mg kg resulted in hypnosis, and at 1.2 mg kg increased reflex suppression was observed. the maximum scores for hypnosis at both doses were obtained 5 minutes after iv injection. the mean (± sd)

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Author

G F Stegmann; L Bester

Publisher

John Wiley and Sons; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 1467-2987)

Published

2001

Language

EN

Field

Veterinary (Health Sciences)