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Can I read Dysmyelination in transgenic mice containing JC virus early region on EtoBox?
Dysmyelination in transgenic mice containing JC virus early region by Dr. Bruce D. Trapp; Judy A. Small; Michael Pulley; George Khoury; George A. Scangos is a Medicine article available to read on EtoBox.
What is Dysmyelination in transgenic mice containing JC virus early region about?
JC virus UCV) causes the chronic human demyelinating disease progressive multifocal leukoencephalopathy. Because of host range restrictions, experimental models of JCV-induced demyelination have not been available. The restricted tropism of JCV infectivity has recently been overcome by the production of transgenic mice that contain the early region of JCV in all cells. This portion of the DNA encodes JCV T-antigens. These mice display a dysmyelinating phenotype, the severity of which is related to the level of JCV early region expression in brain. With the use of immunocytochemistry and in situ hybridization, we characterized morphologically myelin-specific and JCV gene expression in a severely affected strain of these mice. Our results suggest that expression of JCV T-antigens occurs predominantly in oligodendrocytes and is the primary cause of dysmyelination. Affected oligodendrocytes do not myelinate axons properly. However, they express myelin-specific genes and display some of the morphological phenotypes of early stages of myelination. A decreased ratio between levels of transcriptional and translational products of genes encoding the major structural proteins of central nerv
Who reads Dysmyelination in transgenic mice containing JC virus early region?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. Bruce D. Trapp; Judy A. Small; Michael Pulley; George Khoury; George A. Scangos
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)
- Published
- 1988
- Language
- EN
- Field
- Medicine (Health Sciences)