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Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic β-catenin in Min mice by Anne-Maria Pajari; Johanna Rajakangas; Essi Päivärinta; Veli-Matti Kosma; Joseph Rafter; Marja Mutanen is a Medicine article available to read on EtoBox.

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## Abstract Inulin, polydisperse β (2‐1) fructan, has been suggested to protect against colon carcinogenesis and is currently used in a number of food applications. However, the data regarding the role of inulin in intestinal carcinogenesis remains controversial since the results of our previous study suggested that inulin promotes intestinal tumor formation in Min mice, an animal model for intestinal cancer with a mutation in the __Apc__ tumor suppressor gene (__Carcinogenesis__ 2000;21:1167–73). In our present study, we further examined the effects of inulin on intestinal tumor formation in Min mice by carefully analyzing β‐catenin expression and cellular localization at 3 different time points during the tumorigenic process. Min mice were fed a high‐fat inulin‐enriched (10% w/w) diet or the high‐fat diet without any added fiber from the age of 6 weeks to the ages of 9, 12 or 15 weeks. The results showed that inulin significantly increased the number (by 20%) and especially the size (by 44%) of adenomas in the small intestine. At week 15, the promotion of tumor development was accompanied by an accumulation of cytosolic β‐catenin in the adenoma tissue. In the normal appearing muc

Who reads Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic β-catenin in Min mice?

Author

Anne-Maria Pajari; Johanna Rajakangas; Essi Päivärinta; Veli-Matti Kosma; Joseph Rafter; Marja Mutanen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2003

Language

EN

Field

Medicine (Health Sciences)