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Exploration of the Biomarkers of Comorbidity of Psoriasis with Inflammatory Bowel Disease and Their Association with Immune Infiltration by Rui‐Lian Ding; Yu Zheng; Jin Bu is a Medicine article available to read on EtoBox.

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## Abstract ## Background There was evidence that significant bidirectional associations between psoriasis and inflammatory bowel diseases (IBDs), which influences management strategy of the patients, so the investigation on the mechanisms by which these two diseases co‐occur is important. ## Methods The Gene Expression Omnibus (GEO) database was used to download gene expression profiles of psoriasis and IBD. The differentially expressed genes (DEGs) between disease and health control groups for each data set were calculated, and Venn diagram was used to obtain for intersection. We performed Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis on the intersection, followed by developing a protein–protein interaction network and module construction, and identified hub genes by cytoHubba. Thereafter, least absolute shrinkage and selection operator algorithms was used to identify the co‐biomarkers of psoriasis and IBD from the top 50 hub genes. The biomarkers were used to construct a screening model, the discriminatory capacity of which was verified by receiver operating characteristic (ROC) curves. CIBERSORT algorithm was utilized to estimate the

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Author

Rui‐Lian Ding; Yu Zheng; Jin Bu

Publisher

John Wiley and Sons Inc.

Published

2023

Language

EN

Field

Medicine (Health Sciences)