Opening book details…
Can I read A Review on the Cleavage Priming of the Spike Protein on Coronavirus by Angiotensin-converting Enzyme-2 and Furin on EtoBox?
A Review on the Cleavage Priming of the Spike Protein on Coronavirus by Angiotensin-converting Enzyme-2 and Furin by Anwarul Hasan; Bilal Ahamad Paray; Arif Hussain; Fikry Ali Qadir; Farnoosh Attar; Falah Mohammad Aziz; Majid Sharifi; Hossein Derakhshankhah; Behnam Rasti; Masoumeh Mehrabi; Koorosh Shahpasand; Ali Akbar Saboury; Mojtaba Falahati is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A Review on the Cleavage Priming of the Spike Protein on Coronavirus by Angiotensin-converting Enzyme-2 and Furin about?
The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species. Angiotensin-converting enzyme-2 (ACE-2) is one of the most important receptors on the cell membrane of the host cells (HCs) which its interaction with spike protein (SP) with a furin-cleavage site results in the SARS-CoV-2 invasion. Hence, in this review, we presented an overview on the interaction of ACE-2 and furin with SP. As several kinds of CoVs, from various genera, have at their S1/S2 binding site a preserved site, we further surveyed the role of furin cleavage site (FCS) on the life cycle of the CoV. Furthermore, we discussed that the small molecular inhibitors can limit the interaction of ACE-2 and furin with SP and can be used as potential therapeutic platforms to combat the spreading CoV epidemic. Finally, some ongoing challenges and future prospects for the development of potential drugs to promote targeting specific activities of the CoV were reviewed. In conclusion, this review may pave the way for providing useful information about different compounds
Who reads A Review on the Cleavage Priming of the Spike Protein on Coronavirus by Angiotensin-converting Enzyme-2 and Furin?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Anwarul Hasan; Bilal Ahamad Paray; Arif Hussain; Fikry Ali Qadir; Farnoosh Attar; Falah Mohammad Aziz; Majid Sharifi; Hossein Derakhshankhah; Behnam Rasti; Masoumeh Mehrabi; Koorosh Shahpasand; Ali Akbar Saboury; Mojtaba Falahati
- Publisher
- Adenine Press; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 0739-1102)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)