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Uncovering the effects of gender affirming hormone therapy on skeletal muscle and epigenetics: protocol for a prospective matched cohort study in transgender individuals (the GAME study) by Patrice R Jones; Sarah Voisin; Brendan J Nolan; Shanie Landen; Macsue Jacques; Beau Newell; Sav Zwickl; Teddy Cook; Alex Wong; Ariel Ginger; Andrew Palmer; Andrew Garnham; Javier Alvarez-Romero; Namitha Mohandas; Kirsten Seale; Ada Cheung; Nir Eynon is a Medicine article available to read on EtoBox.

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## Introduction Gender affirming hormone therapy (GAHT) is increasingly used by transgender individuals and leads to shifts in sex hormone levels. Skeletal muscle is highly responsive to hormone activity, with limited data on the effects of GAHT on different human tissues. Here, we present the protocol for the GAME study (the effects of Gender Affirming hormone therapy on skeletal Muscle training and Epigenetics), which aims to uncover the effects of GAHT on skeletal muscle ‘omic’ profiles (methylomics, transcriptomics, proteomics, metabolomics) and markers of skeletal muscle health and fitness. ## Methods and analysis This study is a prospective age-matched cohort study in transgender adults commencing GAHT (n=80) and age-matched individuals not commencing GAHT (n=80), conducted at Austin Health and Victoria University in Victoria, Australia. Assessments will take place prior to beginning GAHT and 6 and 12 months into therapies in adults commencing GAHT. Age-matched individuals will be assessed at the same time points. Assessments will be divided over three examination days, involving (1) aerobic fitness tests, (2) muscle strength assessments and (3) collection of blood and muscle

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Author

Patrice R Jones; Sarah Voisin; Brendan J Nolan; Shanie Landen; Macsue Jacques; Beau Newell; Sav Zwickl; Teddy Cook; Alex Wong; Ariel Ginger; Andrew Palmer; Andrew Garnham; Javier Alvarez-Romero; Namitha Mohandas; Kirsten Seale; Ada Cheung; Nir Eynon

Publisher

BMJ

Published

2022

Language

EN

Field

Medicine (Health Sciences)