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FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans by Jiamiao Lu; William L Dentler; Erik A Lundquist is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background In the __C. elegans__ germ line, syncytial germ line nuclei are arranged at the cortex of the germ line as they exit mitosis and enter meiosis, forming a nucleus-free core of germ line cytoplasm called the rachis. Molecular mechanisms of rachis formation and germ line organization are not well understood. ## Results Mutations in the __fli-1__ gene disrupt rachis organization without affecting meiotic differentiation, a phenotype in __C. elegans__ referred to here as the germ line morphogenesis (Glm) phenotype. In __fli-1__ mutants, chains of meiotic germ nuclei spanned the rachis and were partially enveloped by invaginations of germ line plasma membrane, similar to nuclei at the cortex. Extensions of the somatic sheath cells that surround the germ line protruded deep inside the rachis and were associated with displaced nuclei in __fli-1__ mutants. __fli-1__ encodes a molecule with leucine-rich repeats and gelsolin repeats similar to Drosophila flightless 1 and human Fliih, which have been shown to act as cytoplasmic actin regulators as well as nuclear transcriptional regulators. Mutations in __let-60 Ras__, previously implicated in germ line development, were found to

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Author

Jiamiao Lu; William L Dentler; Erik A Lundquist

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-213X)

Published

2008

Language

AF

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)