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Can I read Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver on EtoBox?
Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver by Xiaohong Zhang; Tiantian Zhao; Weiying Liu; Jing Xi; Ding Yao; Yiyi Cao; Xinyue You; Jiaying Wu; Zhenna Gao; Yuyang Lei; Changhui Zhou; Xinyu Zhang; Jiang Zheng; Yang Luan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver about?
Environmental pollutants, such as quinoline (QN) and 4-methylquinoline (4-MeQ), may be genotoxic and carcinogenic. Earlier studies, including in vitro genotoxicity tests, indicated that 4-MeQ is more mutagenic than QN. However, we hypothesized that the methyl group of 4-MeQ favors detoxication over bioactivation, and this factor may be overlooked in in vitro tests that do not incorporate supplementation with cofactors for enzymes that catalyze conjugation reactions. We used human induced hepatocyte cells (hiHeps), which express such enzymes, and compared the genotoxicity of 4-MeQ and QN. We also carried out an in vivo micronucleus (MN) test in rat liver, since 4-MeQ is not genotoxic in rodent bone marrow. In the Ames test and the Tk gene mutation assay, with rat S9 activation, 4-MeQ was more mutagenic than QN. However, QN induced significantly higher MN frequencies in hiHeps and rat liver than did 4-MeQ. Furthermore, QN upregulated genotoxicity marker genes much more than did 4-MeQ. We also investigated the roles of two important detoxication enzymes, UDP-glucuronosyltransferases (UGTs) and cytosolic sulfotransferases (SULTs). When hiHeps were preincubated with hesperetin (UGT inhi
Who reads Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xiaohong Zhang; Tiantian Zhao; Weiying Liu; Jing Xi; Ding Yao; Yiyi Cao; Xinyue You; Jiaying Wu; Zhenna Gao; Yuyang Lei; Changhui Zhou; Xinyu Zhang; Jiang Zheng; Yang Luan
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)