Can I read Neoadjuvant Gemcitabine and Nab‐paclitaxel for Borderline Resectable Pancreatic Cancers: Intention‐to‐treat Analysis Compared with Upfront Surgery on EtoBox?

Neoadjuvant Gemcitabine and Nab‐paclitaxel for Borderline Resectable Pancreatic Cancers: Intention‐to‐treat Analysis Compared with Upfront Surgery by Inoue, Yosuke; Saiura, Akio; Oba, Atsushi; Ono, Yoshihiro; Mise, Yoshihiro; Ito, Hiromichi; Sasaki, Takashi; Ozaka, Masato; Sasahira, Naoki; Takahashi, Yu is a Medicine article available to read on EtoBox.

What is Neoadjuvant Gemcitabine and Nab‐paclitaxel for Borderline Resectable Pancreatic Cancers: Intention‐to‐treat Analysis Compared with Upfront Surgery about?

## Background/purpose: We evaluated efficacy of neoadjuvant therapy with gemcitabine and nab-paclitaxel (gnp-nat) in borderline resectable pancreatic cancer (br-pc) patients compared to conventional upfront surgery (ups). ## Methods: This single-center retrospective study assessed 151 consecutive patients: 96 diagnosed in 2008-2014 underwent ups (ups group) and 55 diagnosed in 2015-2017 underwent gnp-nat (gn group). patient background, surgical, pathological, and survival outcomes were compared between groups. ## Results: Age, sex, and pretreatment carbohydrate antigen 19-9 were similar between groups. after four courses of nat-gnp, 46 gn patients (84%) underwent surgery while all ups patients underwent surgery. only three gn patients (5%) underwent non-therapeutic procedures, compared to 23 (24%) in the ups group (p = .004). in the whole cohort, r0-resection was achieved in 40 gn patients (73%) vs 46 ups patients (48%; p = .004) and the 3-year overall survival was significantly higher in the gn group (median survival time, 31.9 vs 18.1 months, p = .014). in the resection cohort, the r0-resection rate was 93% (gn) vs 63% (ups; p = .0007). there was no 90-day mortalities in either g

Who reads Neoadjuvant Gemcitabine and Nab‐paclitaxel for Borderline Resectable Pancreatic Cancers: Intention‐to‐treat Analysis Compared with Upfront Surgery?

Author

Inoue, Yosuke; Saiura, Akio; Oba, Atsushi; Ono, Yoshihiro; Mise, Yoshihiro; Ito, Hiromichi; Sasaki, Takashi; Ozaka, Masato; Sasahira, Naoki; Takahashi, Yu

Publisher

Springer Japan; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; Publons (ISSN 1868-6974)

Published

2020

Language

EN

Field

Medicine (Health Sciences)