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Loss of expression of theDRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma by Liang Wang; John Darling; Jin-San Zhang; Wanguo Liu; Junqi Qian; David Bostwick; Lynn Hartmann; Robert Jenkins; Walter Bardenhauer; Jochen Schutte; Bertram Opalka; David I. Smith is a Medicine article available to read on EtoBox.

What is Loss of expression of theDRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma about?

Consistent deletion of DNA sequences in chromosomal band 3p21 observed in a variety of human tumors suggests the presence of one or more tumor suppressor genes within this region. Previously, we reported on the construction of two distinct cosmid contigs and our identification of several new genes within 3p21.1. In our search for tumor suppressor genes from this region, we have cloned a gene that we have called DRR 1 (downregulated in renal cell carcinoma). The gene was first mapped to 3p21.1 by fluorescence in situ hybridization analysis. Further analysis of yeast artificial chromosome clones in 3p14.2-p21.1 refined its localization. DRR 1 spans about 10 Kb of genomic DNA with a 3.5-Kb mature transcript. The putative protein encoded by this gene is 144 amino acids and includes a nuclear localization signal and a coiled domain. The gene showed loss of expression in eight of eight renal cell carcinoma cell lines, one of seven ovarian cancer cell lines, one of one cervical cancer cell line, one of one gastric cancer cell line, and one of one non-small-cell lung cancer cell line. Southern blot analysis did not show any altered bands, indicating that gross structural changes or deletio

Who reads Loss of expression of theDRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma?

Author

Liang Wang; John Darling; Jin-San Zhang; Wanguo Liu; Junqi Qian; David Bostwick; Lynn Hartmann; Robert Jenkins; Walter Bardenhauer; Jochen Schutte; Bertram Opalka; David I. Smith

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2000

Language

EN

Field

Medicine (Life Sciences)