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Aminorex and Rexamino as Metabolites of Levamisole in the Horse by E.N.M. Ho; D.K.K. Leung; G.N.W. Leung; T.S.M. Wan; A.S.Y. Wong; C.H.F. Wong; L.R. Soma; J.A. Rudy; C. Uboh; R. Sams is a Chemistry article available to read on EtoBox.

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Administration studies of levamisole in horses were carried out using two different levamisole preparations, namely, levamisole hydrochloride oral bolus and levamisole phosphate injectable solution. These preparations were analysed in detail for the presence of aminorex-like impurities. Both levamisole preparations were found to contain 1-(2-mercaptoethyl)-4-phenyl-2-imidazolidinone (I) and 4-phenyl-2imidazolidinone (II) as degradation impurities, but neither aminorex nor rexamino was detected in these preparations. After the administration of these preparations to horses, aminorex, rexamino, in addition to levamisole and compound II, were detected in post-administration urine and plasma samples, among which compound II was found to have the longest detection time. Administration study of compound II was then performed on another horse to investigate whether it could be a metabolic precursor of aminorex and/or rexamino. However, no aminorex and rexamino was detected in the post-administration samples, suggesting that compound II was not a metabolic precursor of aminorex or rexamino. A metabolite (III) of compound II, tentatively identified to be a hydrolysis product of compound II,

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Author

E.N.M. Ho; D.K.K. Leung; G.N.W. Leung; T.S.M. Wan; A.S.Y. Wong; C.H.F. Wong; L.R. Soma; J.A. Rudy; C. Uboh; R. Sams

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0003-2670)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)