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Expression of the neural cell adhesion molecule (NCAM) and polysialic acid during taste bud degeneration and regeneration by Dr. David V. Smith; Raisa Klevitsky; Richard A. Akeson; Michael T. Shipley is a Neuroscience article available to read on EtoBox.

What is Expression of the neural cell adhesion molecule (NCAM) and polysialic acid during taste bud degeneration and regeneration about?

## Abstract Taste receptor cells are replaced throughout life, accompanied by continuing synaptogenesis between newly formed taste cells and first‐order gustatory fibers. The neural cell adhesion molecule (NCAM) is expressed by a subset of taste cells in adult rodents and appears on gustatory nerve fibers during development prior to differentiation of the taste buds. We employed antibodies against the extracellular domain of the NCAM polypeptide (mAb 3F4) and against polysialic acid (PSA) residues found on embryonic forms of NCAM (mAb 5A5) to investigate the relationship between the expression of these molecules and the innervation of taste buds in adult rats. In unoperated rats, anti‐NCAM recognized a subset of cells within the vallate taste buds and also the fibers of the glossopharyngeal (IXth) nerve, including those innervating the gustatory epithelium. Taste bud cells did not express PSA but mAb 5A5 immunoreactivity was observed on some fibers of the IXth nerve, including a few that entered the taste buds. Bilateral crush of the IXth nerve resulted in the loss of NCAM expression from the gustatory epithelium within 8 days. As IXth nerve fibers reinnervated the epithelium, NCAM

Who reads Expression of the neural cell adhesion molecule (NCAM) and polysialic acid during taste bud degeneration and regeneration?

Author

Dr. David V. Smith; Raisa Klevitsky; Richard A. Akeson; Michael T. Shipley

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1994

Language

EN

Field

Neuroscience (Life Sciences)