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CRY1Δ11 Mutation Linked to ADHD Symptoms by DANIEL ESTEBAN BARRERA PLAZAS is a document available to read on EtoBox.
The study investigates the Cry1Δ11 mutation, which is linked to ADHD-like symptoms, revealing that Cry1Δ11 mice exhibit hyperactivity, impulsivity, and learning deficits due to hyperactive dopamine D1 receptor signaling. The mutation disrupts the interaction between the CRY1Δ11 protein and Gαs protein, leading to increased neuronal excitability in dopamine D1 receptor-expressing neurons. The findings suggest that targeting DRD1 signaling may provide a therapeutic approach for ADHD associated with the CRY1Δ1
- Author
- DANIEL ESTEBAN BARRERA PLAZAS
- Language
- EN