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A Botanical Containing Freeze Dried Açai Pulp Promotes Healthy Aging and Reduces Oxidative Damage in Sod1 Knockdown Flies by Mara Laslo; Xiaoping Sun; Cheng-Te Hsiao; Wells W. Wu; Rong-Fong Shen; Sige Zou is a Medicine article available to read on EtoBox.

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Superoxide dismutase 1 (SOD1), a critical enzyme against oxidative stress, is implicated in aging and degenerative diseases. We previously showed that a nutraceutical containing freeze-dried açai pulp promotes survival of flies fed a high-fat diet or sod1 knockdown flies fed a standard diet. Here, we investigated the effect of açai supplementation initiated at the early or late young adulthood on lifespan, physiological function, and oxidative damage in sod1 knockdown flies. We found that Açai supplementation extended lifespan even when started at the age of 10 days, which is the time shortly before the mortality rate of flies accelerated. Life-long açai supplementation increased lifetime reproductive output in sod1 knockdown flies. Our molecular studies indicate that açai supplementation reduced the protein levels of genes involved in oxidative stress response, cellular growth, and nutrient metabolism. Açai supplementation also affected the protein levels of ribosomal proteins. In addition, açai supplementation decreased the transcript levels of genes involved in oxidative stress response and gluconeogenesis, while increasing the transcript levels of mitochondrial biogenesis genes

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Author

Mara Laslo; Xiaoping Sun; Cheng-Te Hsiao; Wells W. Wu; Rong-Fong Shen; Sige Zou

Publisher

Springer Science and Business Media LLC

Published

2012

Language

EN

Field

Medicine (Health Sciences)