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Mutations of the BIK gene in human peripheral B-cell lymphomas by Vincenzo Arena; Maurizio Martini; Myriam Luongo; Arnaldo Capelli; Luigi Maria Larocca is a Medicine article available to read on EtoBox.
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## Abstract BIK, a BH (Bcl2 homology domain)3‐only protein, is a proapoptotic member of the BCL2 family. We performed single‐strand conformational polymorphism and sequencing analysis of the entire coding region of the __BIK__ gene (exons 2–5) in 71 B‐cell lymphomas [27 follicular lymphomas (FLs), 13 marginal cell lymphomas (MZLs), 7 small lymphocytic lymphomas (SLLs), 6 mantle cell lymphomas (MCLs), 2 lymphoplasmacytic lymphomas, and 16 diffuse large B‐cell lymphomas (DLBCLs)]. Missense __BIK__ gene mutations were observed in 3 of 27 (11%) FLs, in 2 of 13 (15%) MZLs, and in 1 of 16 (6%) DLBCLs. Sequence alterations in intronic regions were observed in 4 of 27 (14.8%) FLs, in 7 of 13 (53%) MZLs, and in 3 of 16 (18%) DLBCLs. These data indicate that mutation of the __BIK__ gene is a frequent feature of B‐cell lymphomas. © 2003 Wiley‐Liss, Inc.
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- Author
- Vincenzo Arena; Maurizio Martini; Myriam Luongo; Arnaldo Capelli; Luigi Maria Larocca
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Life Sciences)