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Synthesis and characterization of an amphiphilic graft polymer and its potential as a pH-sensitive drug carrier by Yi Li; Hye Jung Heo; Guang Hui Gao; Seong Woo Kang; Cong Truc Huynh; Min Sang Kim; Jae Won Lee; Jung Hee Lee; Doo Sung Lee is a Materials Science article available to read on EtoBox.

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The synthesis and properties of a new pH-sensitive polymer Poly(3-caprolactone) Grafted Poly(ethylene glycol) Based Poly(ß-amino ester) (PEGAE-g-PCL) are described here. The successful synthesis of the graft copolymer was confirmed by 1 H NMR. The self-assemble behavior of the amphiphilic polymer was investigated using pyrene as a probe. Dynamic light scattering (DLS) showed that the polymeric micelles had a size of 60 nm at physiological pH and were responsive to pH. A spherical morphology was observed for the micelles using transmission electron microscopy (TEM). Zeta-potential measurement at different pH showed that the micelles were neutral at pH 7.4 and positively charged at lower pH. Doxorubicin (DOX) was used as a model drug and loaded in the micelles. The drug loaded micelles showed a slow and pH-dependant drug release behavior. The remaining hydroxyl groups on the main chain made it possible the further conjugation of imaging agents or targeting groups.

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Author

Yi Li; Hye Jung Heo; Guang Hui Gao; Seong Woo Kang; Cong Truc Huynh; Min Sang Kim; Jae Won Lee; Jung Hee Lee; Doo Sung Lee

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0032-3861)

Published

2011

Language

EN

Field

Materials Science (Physical Sciences)