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An Expeditious Synthesis Of Quinolone Antibacterials by Majid M. Heravi; Hossein A. Oskooie; Radineh Motamedi; Mitra Ghassemzadeh is a Chemistry article available to read on EtoBox.
What is An Expeditious Synthesis Of Quinolone Antibacterials about?
A facile and rapid synthesis of ciprofloxacin under microwave irradiation is described. The product ciprofloxacin was isolated and the impurity was characterized as the product of substitution of fluorine instead of chlorine in acid 1. Similarly norfloxacin was synthesized. Quinolones represent a large family of synthetic antibacterial agents, which inhibits the two important bacterial enzymes and are characterized by a broad spectrum antibacterial activity (1). The fluoro derivatives of these compounds are the latest addition to the therapeutic agents that are presently used in clinical practice to fight Mycobacterium tubercular infections (2). Among them ciprofloxacin 2a and norfloxacin 2b are widely used antibiotics in bulk quantities. In fact 2a is the most widely used as third generation quinolone antibiotic in the world and is superior to chloroamphenicol, aminoglycosides and cephalosporin and commonly used for curing enteric fever, septicaemici, bronchopeneiemonia aestrogelitis, prostates and non-genococial arethritis (3). 2a and 2b are commonly prepared by the substitution reaction of an appropriate acid la and lb with piperazine (4). Use of borate or fluoroborate complex o
Who reads An Expeditious Synthesis Of Quinolone Antibacterials?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Majid M. Heravi; Hossein A. Oskooie; Radineh Motamedi; Mitra Ghassemzadeh
- Publisher
- Walter de Gruyter GmbH
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)