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Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes by Gozewijn D. Laverman; Harry van Goor; Robert H. Henning; Paul E. de Jong; Dick de Zeeuw; Gerjan Navis is a Medicine article available to read on EtoBox.
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## Background: Control of blood pressure (bp) and optimal reduction of proteinuria (uprot) are necessary for long-term renoprotection. unfortunately, angiotensin-converting enzyme inhibitors (acei) and angiotensin ii (ang ii) antagonists are not effective during sodium repletion. vasopeptidase inhibitors (vpi) cause dual inhibition of ace and neutral endopeptidase, the latter resulting in decreased atrial natriuretic peptide (anp) breakdown and thus enhanced natriuresis. therefore, in contrast with acei, vpi may be effective during high sodium intake. ## Methods: To test this hypothesis, the renoprotective actions of the new vpi gemopatrilat (gem) were studied during low (0.05% nacl) and high (3.0% nacl) sodium diets in normotensive wistar rats with established adriamycin nephrosis. the acei lisinopril (lis) was used as control. rats received either gem (0.3 mg/g chow), an equihypotensive dose of lis (75 mg/l drinking water), or vehicle (veh) from week 6 (that is, established uprot) until sacrifice. the effect of therapy was monitored by measuring systolic bp and uprot (weekly) and structural renal damage at the end of study (week 16). ## Results: During low sodium, gem effectively
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- Author
- Gozewijn D. Laverman; Harry van Goor; Robert H. Henning; Paul E. de Jong; Dick de Zeeuw; Gerjan Navis
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)