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Global epidemiological burden of fungal infections in cirrhosis patients: A systematic review with meta‐analysis by Nipun Verma; Shreya Singh; Manvi Singh; Anil Chauhan; Pranita Pradhan; Nishant Jaiswal; Arunaloke Chakrabarti; Meenu Singh is a Medicine article available to read on EtoBox.
What is Global epidemiological burden of fungal infections in cirrhosis patients: A systematic review with meta‐analysis about?
## Abstract ## Background and Aims Fungal infections (FIs) have serious implications, yet understated in cirrhosis. Therefore, we reviewed the epidemiology and trends of FIs among cirrhotics. ## Methods Four electronic databases were searched for full‐text articles describing prevalence of FIs in cirrhosis. Studies from post‐transplant, malignancy and classical‐immuno‐deficiency patients were excluded. A random‐effects meta‐analysis was done to pool estimates of FIs (overall, and by type and infection‐site), and their variation(I^2^) was explored on moderator‐analysis and meta‐regression. Risk of bias and asymmetry in estimates was assessed by a checklist and Egger's regression, respectively.(CRD42019142782). ## Results Thirty‐four low‐risk and four moderate‐risk studies (31 984 cirrhotics) were included. Pooled estimates of overall FIs (17 studies), invasive fungal infections (IFIs; 17 studies), invasive candidiasis (23 studies) and invasive aspergillosis (16 studies) in cirrhosis were 10.2%(6.0‐16.9), 9.5%(5.4‐16.2), 4.0%(2.0‐8.0) and 2.8%(1.5‐5.3), respectively (I^2^ > 90%;each). Site of FIs in decreasing order of pooled prevalence was pulmonary, urinary tract, bloodstream, peri
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- Author
- Nipun Verma; Shreya Singh; Manvi Singh; Anil Chauhan; Pranita Pradhan; Nishant Jaiswal; Arunaloke Chakrabarti; Meenu Singh
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)