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Can I read Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action on EtoBox?
Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action by Dai, Ziwen; Wang, Zhigang is a Chemistry article available to read on EtoBox.
What is Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action about?
Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is able to reduce side effects, and the novel mechanism of action of photoactivatable platinum drugs might also conquer the resistance. In this review, the recent advances in the design of photoactivatable platinum-based drugs were summarized. The complexes are classified according to their mode of action, including photoreduction, photo-uncaging, and photodissociation. The rationale of drug design, dark stability, photoactivation process, cytotoxicity, and mechanism of action of typical photoactivatable platinum drugs were reviewed. Finally, the challenges and opportunities for designing more potent photoactivatable platinum drugs were discussed.
Who reads Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Dai, Ziwen; Wang, Zhigang
- Publisher
- Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Berlin: Springer, 1996-; Basel: 1997-; Springer Science and Business Media LLC (ISSN 1420-3049)
- Published
- 2020
- Language
- EN
- Field
- Chemistry (Life Sciences)