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Engineered Measles Virus as a Novel Oncolytic Therapy Against Prostate Cancer by Pavlos Msaouel; Ianko D. Iankov; Cory Allen; John C. Morris; Veronika von Messling; Roberto Cattaneo; Michael Koutsilieris; Stephen J. Russell; Evanthia Galanis is a Medicine article available to read on EtoBox.

What is Engineered Measles Virus as a Novel Oncolytic Therapy Against Prostate Cancer about?

## Abstract ## BACKGROUND No curative therapy is currently available for locally advanced or metastatic prostate cancer. Oncolytic viruses represent a novel class of therapeutic agents that demonstrates no cross‐resistance with existing approaches and can therefore be combined with conventional treatment modalities. Measles virus strains deriving from the Edmonston (MV‐Edm) vaccine strain have shown considerable oncolytic activity against a variety of solid tumers and hematologic malignancies. In this study, we investigated the antitumor potential of recombinant MV‐Edm derivatives as novel oncolytic agents against prostate cancer. ## METHODS The susceptibility of prostate cancer cell lines (PC‐3, DU‐145, and LNCaP) to measles virus infection was demonstrated using an MV‐Edm derivative expressing green fluorescent protein (GFP). MV‐Edm replication in prostate cancer cell lines was assessed by one step viral growth curves. The oncolytic effect of an MV‐Edm strain engineered to express the human carcinoembryonic antigen (CEA) was demonstrated in vitro by MTT assays and in vivo in subcutaneous PC‐3 xenografts. CEA levels were quantitated in cell supernatants and mouse serum samples. ##

Who reads Engineered Measles Virus as a Novel Oncolytic Therapy Against Prostate Cancer?

Author

Pavlos Msaouel; Ianko D. Iankov; Cory Allen; John C. Morris; Veronika von Messling; Roberto Cattaneo; Michael Koutsilieris; Stephen J. Russell; Evanthia Galanis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2008

Language

EN

Field

Medicine (Health Sciences)