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Metabolic Engineering Challenges in the Post-genomic Era by Hal Alper; Gregory Stephanopoulos is a Engineering article available to read on EtoBox.

What is Metabolic Engineering Challenges in the Post-genomic Era about?

Metabolic engineering is a young field, just over ten-years old. During this period, it has developed a well-defined methodology and a focused research portfolio of rich intellectual content and particular relevance to biotechnology and biological engineering. New and diverse opportunities for metabolic engineering emerge quickly in this genomic era. Although the focus (e.g. improving cells) and central components (e.g. assessing cell physiology) of metabolic engineering remain the same, new tools are required to take advantage of the opportunities arising from the availability of whole-genome sequence information. Cellular phenotype is a manifestation of gene expression levels, metabolic demand, resource availability, and cellular stresses. Above all, metabolic function is constrained by the stoichiometry and individual reaction kinetics of the reaction network. To understand the behavior of these systems, the well-established framework of reaction engineering must be complemented with new experimental methods specifically designed for the elucidation of metabolic pathways and bioreaction networks. Most of all, a combination of rational and combinatorial approaches is required to

Who reads Metabolic Engineering Challenges in the Post-genomic Era?

Author

Hal Alper; Gregory Stephanopoulos

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0009-2509)

Published

2004

Language

EN

Field

Engineering (Physical Sciences)