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Comparison of neutralization of BPV-1 infection of C127 cells and bovine fetal skin xenografts by Shinje Ghim; Neil D. Christensen; John W. Kreider; A. Bennett Jenson is a Medicine article available to read on EtoBox.
What is Comparison of neutralization of BPV-1 infection of C127 cells and bovine fetal skin xenografts about?
BPV-I induces focus formation in murine C127 cells and fibropapillomas in bovine fetal skin xenografts. In this study, we compared the specificity of neutralization of BPV-I in both assay systems, using sera and monoclonal antibodies (MAbs) selected to define neutralizing epitopes. Sera from rabbits and cattle, inoculated with intact BPV-I or BPV-2 virions, neutralize BPV-I infectivity in both C I27 cells and xenografts. Selected human sera and murine MAbs that react with intact BPV-I particles, serum of a rabbit immunized with denatured BPV-I particles, and sera from calves vaccinated with a recombinant LI fusion protein did not neutralize BPV-I infection in either system. It was concluded that neutralization of BPV-I infection of C I27 cells and bovine fetal skin xenografts by hyperimmune sera is specific and concordant for both assay systems, and involves conformational BPV-I capsid epitopes.
Who reads Comparison of neutralization of BPV-1 infection of C127 cells and bovine fetal skin xenografts?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shinje Ghim; Neil D. Christensen; John W. Kreider; A. Bennett Jenson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1991
- Language
- EN
- Field
- Medicine (Health Sciences)