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Prognostic Value of Survivin in Locally Advanced Prostate Cancer: Study Based on RTOG 8610 by Min Zhang; Alex Ho; Elizabeth H. Hammond; Yoshiyuki Suzuki; R. Scott Bermudez; R. Jeffrey Lee; Michael Pilepich; William U. Shipley; Howard Sandler; Li-Yan Khor; Alan Pollack; Arnab Chakravarti is a Medicine article available to read on EtoBox.

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## Purpose: To examine the prognostic value of nuclear and cytoplasmic survivin expression in men with locally advanced prostate cancer who were enrolled in radiation therapy oncology group (rtog) protocol 8610. ## Methods and materials: Rtog 8610 was a phase iii randomized study comparing the effect of radiotherapy plus short-term androgen deprivation with radiotherapy alone. of the 456 eligible patients, 68 patients had suitably stained tumor material for nuclear survivin analysis and 65 patients for cytoplasmic survivin. ## Results: Compared with patients with nuclear survivin intensity scores of 191.2 had significantly improved prostate cancer survival (hazard ratio [hr], 0.45; 95% confidence interval [ci], 0.20-1.00, p = 0.0452). on multivariate analysis, nuclear survivin intensity scores >191.2 were significantly associated with improved overall survival (hr, 0.46; 95% ci, 0.25-0.86; p = 0.0156) and prostate cancer survival (hr, 0.36; 95% ci, 0.16-0.84; p = 0.0173). on univariate analysis, compared with patients with cytoplasmic survivin integrated optical density 82.7 showed a significantly increased risk of local progression (hr, 2.49; 95% ci, 1.03-6.01; p = 0.0421). ## Con

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Author

Min Zhang; Alex Ho; Elizabeth H. Hammond; Yoshiyuki Suzuki; R. Scott Bermudez; R. Jeffrey Lee; Michael Pilepich; William U. Shipley; Howard Sandler; Li-Yan Khor; Alan Pollack; Arnab Chakravarti

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2009

Language

EN

Field

Medicine (Health Sciences)