Can I read Design and synthesis of sialyl Lewis^x^ mimics as E‐ and P‐selectin inhibitors on EtoBox?

Design and synthesis of sialyl Lewis^x^ mimics as E‐ and P‐selectin inhibitors by Neelu Kaila; Bert E. Thomas IV is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Design and synthesis of sialyl Lewis^x^ mimics as E‐ and P‐selectin inhibitors about?

## Abstract The selectins are a family of cell‐adhesion proteins that mediate the rolling of leukocytes on activated endothelial cells through the recognition of the carbohydrate epitope sialyl Lewis^x^ (sLe^x^). Control of the leukocyte‐endothelial cell adhesion process may prove useful in cases where excess recruitment of leukocytes can contribute to acute diseases such as stroke and reperfusion injury and chronic diseases such as psoriasis and rheumatoid arthritis. The development of molecules that block the interactions between sLe^x^ and the selectins has become an active area of research. In this review, we will highlight the various approaches taken toward the development of sLe^x^ mimetics as antagonists of E‐ and P‐selectin, including the use of structural information about the selectins and their interactions with sLe^x^ that have been revealed through the use of NMR, protein crystallography and molecular modeling. © 2002 Wiley Periodicals, Inc. Med Res Rev, 22, No. 6, 566–601, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/med.10018

Who reads Design and synthesis of sialyl Lewis^x^ mimics as E‐ and P‐selectin inhibitors?

Author

Neelu Kaila; Bert E. Thomas IV

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0198-6325)

Published

2002

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)