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The behavior of MC3T3‐E1 cells on chitosan/poly‐L‐lysine composite films: Effect of nanotopography, surface chemistry, and wettability by Zhenhuan Zheng; Ling Zhang; Lijun Kong; Aijun Wang; Yandao Gong; Xiufang Zhang is a Engineering article available to read on EtoBox.

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## Abstract In the present work, a series of composite films were produced from chitosan/poly‐L‐lysine blend solutions. The surface topography, chemistry, and wettability of composite films were characterized by atomic force microscopy (AFM), attenuated total reflection Fourier transform infrared (ATR‐FTIR) spectroscopy, and contact angle assay, respectively. For all composite films, blending with poly‐L‐lysine induced changes in surface chemistry and wettability. Interestingly, it was also found that increasing poly‐L‐lysine weight fraction in blend solutions could result in different nanoscaled surface topographic features, which displayed particle‐, granule‐, or fiber‐dominant morphologies. MC3T3‐E1 osteoblast‐like cells were cultured on all composite films to evaluate the effects of surface nanotopography, chemistry, and wettability on cell behavior. The observations indicated that MC3T3‐E1 cell behavior was affected by surface topography, chemistry, and wettability simultaneously and that cells showed strong responses to surface topography. On fiber‐dominant surface, cells fully spread with obvious cytoskeleton organization and exhibited significantly higher level of adhesion

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Author

Zhenhuan Zheng; Ling Zhang; Lijun Kong; Aijun Wang; Yandao Gong; Xiufang Zhang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2008

Language

EN

Field

Engineering (Physical Sciences)