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Injectable Bubbles for Physiological Pressure Measurement by Pandey, Prashant is a scholarly article available to read on EtoBox.

What is Injectable Bubbles for Physiological Pressure Measurement about?

Microbubbles - used as contrast agents in ultrasound imaging - are important tools in biomedical research, having been used together with ultrasound to develop significant diagnostic and therapeutic techniques. It has been suggested that the dynamic behaviour of microbubbles is dependent on the surrounding fluid's ambient (hydrostatic) pressure, and the potential to non-invasively determine blood pressure has numerous medical applications. To study this dependence, a computational mathematical model was created based on Marmottant's dynamic model of a microbubble. A pulse inversion (PI) protocol was incorporated into the model to emphasize the nonlinear behaviour of the microbubble's response. The mathematical model was also used to assess the sensitivity of the microbubbles to undesirable changes in parameters other than the ambient pressure. It found that a variation in the microbubble's initial radius and surface tension would cause the most significant changes in signal energy and hence pose a risk to ambient pressure measurements. To test the practicality of detecting a change in the dynamic behaviour of microbubbles, in vitro experiments were designed and carried out using cl

Author

Pandey, Prashant

Published

2022

Language

EN