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Can I read Influence of a low dose of amphetamine on vesicular monoamine transporter binding: A PET (+)[^11^C]DTBZ study in humans on EtoBox?
Influence of a low dose of amphetamine on vesicular monoamine transporter binding: A PET (+)[^11^C]DTBZ study in humans by Isabelle Boileau; Sylvain Houle; Pablo M. Rusjan; Yoshiaki Furukawa; Diana Wilkins; Junchao Tong; Peter Selby; Alan A. Wilson; Stephen J. Kish is a Neuroscience article available to read on EtoBox.
What is Influence of a low dose of amphetamine on vesicular monoamine transporter binding: A PET (+)[^11^C]DTBZ study in humans about?
## Abstract We previously reported increased binding of (+)[^11^C]DTBZ (dihydrotetrabenazine), the vesicular monoamine transporter (VMAT2) positron emission tomography (PET) radioligand, in striatum of some methamphetamine users. This finding might be explained by stimulant‐induced vesicular DA depletion resulting in decreased DA (+)[^11^C]DTBZ competition at VMAT2. In a prospective PET study, we now find that administration of an acute oral dose of amphetamine (0.4 mg/kg) to humans does not cause increased striatal (+)[^11^C]DTBZ binding but a slight 5% decrease. Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[^11^C]DTBZ binding and that a higher dose might be required. Synapse 64:417–420, 2010. © 2010 Wiley‐Liss, Inc.
Who reads Influence of a low dose of amphetamine on vesicular monoamine transporter binding: A PET (+)[^11^C]DTBZ study in humans?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Isabelle Boileau; Sylvain Houle; Pablo M. Rusjan; Yoshiaki Furukawa; Diana Wilkins; Junchao Tong; Peter Selby; Alan A. Wilson; Stephen J. Kish
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2010
- Language
- EN
- Field
- Neuroscience (Life Sciences)