Opening book details…
Can I read Recent progress on gene-deleted live-attenuated African swine fever virus vaccines on EtoBox?
Recent progress on gene-deleted live-attenuated African swine fever virus vaccines by Hiep L. X. Vu; D. Scott McVey is a Medicine article available to read on EtoBox.
What is Recent progress on gene-deleted live-attenuated African swine fever virus vaccines about?
## Abstract African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease has spread to many swine-producing countries, leading to significant economic losses and adversely impacting global food security. Extensive efforts have been directed toward developing effective ASF vaccines. Among the vaccinology approaches tested to date, live-attenuated virus (LAV) vaccines produced by rational deleting virulence genes from virulent African Swine Fever Virus (ASFV) strains have demonstrated promising safety and efficacy in experimental and field conditions. Many gene-deleted LAV vaccine candidates have been generated in recent years. The virulence genes targeted for deletion from the genome of virulent ASFV strains can be categorized into four groups: Genes implicated in viral genome replication and transcription, genes from the multigene family located at both 5′ and 3′ termini, genes participating in mediating hemadsorption and putative cellular attachment factors, and novel genes with no known functions. Some promising LAV vaccine candidates are generated by deleting a single viral virulence gene, whereas others are generated by
Who reads Recent progress on gene-deleted live-attenuated African swine fever virus vaccines?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hiep L. X. Vu; D. Scott McVey
- Publisher
- Nature Publishing Group UK
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)